Fatal Metformin Overdose Presenting with Progressive Hyperglycemia

Metabolic acidosis in a patient with metformin overdose.

We report a rare fatal case of acute metformin overdose in a 19-year-old woman.

Diabetes mellitus and renal failure: Prevention and management

Nowadays, diabetes mellitus (DM) and hypertension are considered as the most common causes of end-stage renal disease (ESRD). In this paper, other than presenting the role of DM in ESRD, glucose metabolism and the management of hyperglycemia in these patients are reviewed. Although in several large studies there was no significant relationship found between tight glycemic control and the surviv...

Non-Fatal Amlodipine and Insulin Overdose in an Elderly Person

Repaglinide/metformin fixed-dose combination to improve glycemic control in patients with type 2 diabetes: an update

Type 2 diabetes is a progressive disease associated with high levels of morbidity and mortality and for which there is both a large and growing prevalence worldwide. Lifestyle advice plus metformin is commonly recommended initially to manage hyperglycemia and to minimize the risk of vascular complications. However, additional agents are required when glycemic targets cannot be achieved or maint...

Management of Sitagliptin and Metformin Combination Toxic Overdose.

Metformin and Sitagliptin are often used in combination in the management of non-insulin dependent diabetes mellitus. Though toxicity is rare, but occurs more frequently in cases of intentional or unintentional overdose of these drugs. Here, we present a case of an intentional overdose of a metformin- sitagliptin combination (70g metformin and 3500mg sitagliptin) in a suicide attempt by a young...